Endocrine Abstracts

IntroductionWe report a case of severe thyrotoxicosis due to a metastatic testicular tumor secreting human chorionic gonadotropin (hCG), known to have a TSH-mimicking effect due to alpha-subunits’ structural similarity.Case reportIn November 2020 a 38-year-old man was referred to our Department for thyrotoxicosis of unknown etiology. He had no family history of thyroid disease and his medical history had...

Tumor-induced osteomalacia (TIO) or ‘oncogenic osteomalacia’ is a rare paraneoplastic disorder, usually resulting from Fibroblast Growth Factor 23 (FGF23) oversecretion by a benign small ‘phosphaturic mesenchymal tumor’, causing hypophosphatemia and reduced 1,25-dihydroxyvitamin D synthesis. Calcium and parathyroid hormone (PTH) levels are usually normal, but secondary/tertiary hyperparathyroidism has been reported in up to 5% of the cases, mainly due to 1,...

Pheochromocytoma is a rare catecholamine-secreting tumour arising from chromaffin cells in the adrenal medulla and one of the main causes of endocrine hypertension. We here report the case of a 48-year old man admitted to the Internal Medicine Department for evaluation of resistant hypertension. The patient presented with headache, sweating, palpitations, pitting edema, hypertension and hypokalemia both resistant to conventional polytherapy. He was therefore investigated for e...

Aim of the study: recurrence or persistence of hyperthyroidism occur in 15-25% of cases after radioiodine therapy (RAI) in Graves’ disease (GD). Our study aimed to establish prognostic factors affecting RAI outcome and to investigate if a tailored dosimetric approach based on the application of the “effective biological dose” (BED) offered a higher chance of success.Materials and methods: our cohort comprised 365 GD patients (280 women and...